12, 4 November 2020 | ACS Applied Bio Materials, Vol. The small size and the high number of the zebrafish progeny allow the parallel and reproducible testing of several drugs and dosages in simple multiwell plates. 2458-2466. Magnolia officinalis 8, No. 146, No. Wang YF, Chen IW, Subendran S, Kang CW, Panigrahi B, Fu TF, Chen CY. 6, 15 September 2014 | Nucleic Acids Research, Vol. 6, No. 42, 12 November 2014 | Journal of Dental Research, Vol. 1, 17 November 2009 | Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Vol. In conclusion, the zebrafish presents a powerful in vivo preclinical model for assessing the adverse effects of a wide range of drugs as well as to determine drug efficacy. 16, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. 2, No. 10, No. 15, No. 34, No. Keywords:Zebrafish, drug discovery, drug testing, large-scale screen, chemical genetics, pre-clinical studies. The zebrafish embryo has become an important vertebrate model for assessing drug effects. In vitro Characterization and Release Studies of Combined Nonionic Surfactant-Based Vesicles for the Prolonged Delivery of an Immunosuppressant Model Drug.  |  5, 17 September 2018 | Lab Animal, Vol. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. 4, 19 October 2006 | Angiogenesis, Vol. 47, No. Lateral line neuromasts of zebrafish are a well-established model for the study of drug protection from cisplatin or aminoglycoside toxicity because their HCs are considered homologous to mammalian HCs and readily accessible to compounds in vivo (47–49). PubMed Journals was a successful… 1, 1 October 2020 | Scientific Reports, Vol. 46, No. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. Journal of Medicinal Chemistry 2021, 64, 1, 326-342 (Drug Annotation) ACS Editors' Choice Publication Date (Web) : December 24, 2020 4, 29 April 2020 | Environmental Science & Technology, Vol. Gene therapy gives long-term protection to photoreceptor cells in a mouse model of retinitis pigmentosa Major funding announced to develop materials and cell based treatment for diabetes Large-scale trial will assess effectiveness of teaching mindfulness in UK schools 2020 Nov 12;10(11):1542. doi: 10.3390/biom10111542. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Expert Opin Drug Discov. Dr. Lisa Maves. Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment. Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. 10, No. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. 89, No. 5, South African Journal of Botany, Vol. 1, Journal of Pharmacopuncture, Vol. 11, 23 January 2020 | Journal of Applied Toxicology, Vol. x Biliary atresia (BA) is a fibro-obliterative cholangiopathy that involves both extrahepatic and intrahepatic bile ducts in infants. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. It is well suited for studies in genetics, embryology, development, and cell biology. 93, No. PubMed Journals helped people follow the latest biomedical literature by making it easier to find and follow journals, browse new articles, and included a Journal News Feed to track new arrivals news links, trending articles and important article updates. 242, No. 14, No. In vitro screening of 26 compounds revealed 22 with nanomolar potency against axenically cultured bloodstream trypanosomes. 8, No. 234, No. 656, 3 December 2018 | Marine Drugs, Vol. 29, No. Therefore, we considered the adult zebrafish a useful model for confirming drug candidates determined as positive that should not be further evaluated in subsequent stages. 2, 26 April 2011 | Biomedical Optics Express, Vol. 3, 21 February 2017 | Oncotarget, Vol. Caenorhabditis elegans The zebrafish embryo has become an important vertebrate model for assessing drug effects. 83, Future Medicinal Chemistry, Vol. Author information: (1)Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA 02115, USA. Genesis Drug Discovery & Development (GD3) - fully integrated CRO with a diverse portfolio covering all areas of preclinical drug discovery/development as well as model development for a wide range of therapeutic areas. 6, 21 February 2020 | ACS Chemical Neuroscience, Vol. 293, No. Lee et al (2019) Entosis Controls a Developmental Cell Clearance in C. elegans. Danio rerio Zebrafish. ) models, Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids, Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery, In vivo cardiovascular toxicity induced by acetochlor in zebrafish larvae, Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications, Inhibition of vascular endothelial growth factor-induced angiogenesis by chlorogenic acid via targeting the vascular endothelial growth factor receptor 2-mediated signaling pathway, Measuring the mass, volume, and density of microgram-sized objects in fluid, The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance, Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition, Size does matter – Determination of the critical molecular size for the uptake of chemicals across the chorion of zebrafish (Danio rerio) embryos, Protective effect of (±)-Pestalachloride D, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp. With a high degree of homology to human genome and biological systems, zebrafish embryos can be used to monitor the phenotypic and genotypic abnormalities upon exposure to nanomaterials. 20, No. 9, No. Danio rerio 2014 May;10(5):685-97. doi: 10.1517/17425255.2014.896339. The NexION^® 1000 ICP-MS is the ideal high-throughput system for routine, multi-elemental, trace-level analyses that meet regulatory standards – and that works within your budget. Zebrafish and human auditory systems most likely share an evolutionary origin with those of all vertebrates. Zebrafish as a Preclinical In Vivo Screening Model for Nanomedicines Formulation design and optimization are therefore key steps towards successful nanomedicine development. 40, No. 2, 2 February 2018 | Inventions, Vol. 3, Journal of Developmental Biology, Vol. 7, Neuroscience & Biobehavioral Reviews, Vol. 1-2, 11 July 2008 | PLoS Genetics, Vol. 2, Journal of Biomedical Research, Vol. Molecular testing and analyses of existing drug screen across 537 cancer cell lines validated mitochondrial protease ClpP and ATF4 as ONC201/6 targets. Danio rerio For instance, in a chemical genetic screen testing 2.480 compounds, prostaglandin E2 (PGE2) was identified as an evolutionarily conserved regulator of  |  Biol., Vol. Overall, zebrafish-based test systems have to be validated carefully by comparing them to established protocols. 6, 3 April 2020 | Scientific Reports, Vol. 1, Birth Defects Research Part B: Developmental and Reproductive Toxicology, Vol. 12, 5 October 2018 | BMC Complementary and Alternative Medicine, Vol. 1. 2, No. 2020 Nov 12;8:589503. doi: 10.3389/fchem.2020.589503. 10, 16 February 2018 | Current Protocols in Cytometry, Vol. 5, 1 January 2005 | Nature Reviews Drug Discovery, Vol. 11, No. 27, No. Aspatwar A, Berrino E, Bua S, Carta F, Capasso C, Parkkila S, Supuran CT. J Enzyme Inhib Med Chem. 32, No. 19, pp. Specialized in the efficient development of your preclinical program. 357, No. The effects of compounds on various organs, including the heart, brain, intestine, pancreas, cartilage, liver, and kidney, were observed in the transparent animals without complicated processing, demonstrating the efficiency of toxicity assays using zebrafish embryos. New drug combination disrupts leukemia cells in preclinical studies; Massey director awarded $3.2M to inform the development of novel therapies for blood disorders; Samantha Harris to keynote Women & Wellness Signature Breakfast and Luncheon; Massey biologist studies role of lipids in the development of lung cancer and resistance to chemotherapy Ribeiro LNM, Rodrigues da Silva GH, Couto VM, Castro SR, Breitkreitz MC, Martinez CS, Igartúa DE, Prieto MJ, de Paula E. Front Chem. Channel Blocking in Zebrafish, ZebraBeat: a flexible platform for the analysis of the cardiac rate in zebrafish embryos, Synthesis, Anti-Tumor and Anti-Angiogenic Activity Evaluations of Asiatic Acid Amino Acid Derivatives, Study on early biomarkers of zebrafish liver injury induced by acetaminophen, Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs, Zebrafish as a disease model for studying human hepatocellular carcinoma, Blocking VEGF Signaling Delays Development of Replacement Teeth in Zebrafish, Combining Motion Analysis and Microfluidics – A Novel Approach for Detecting Whole-Animal Responses to Test Substances, Transfer of Silica-Coated Magnetic (Fe3O4) Nanoparticles Through Food: A Molecular and Morphological Study in Zebrafish, Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA, Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing, Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories, Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53, Bioactive 9,11-Secosteroids from Gorgonian 1, 21 April 2015 | Molecules, Vol. 18, No. 201, Journal of Drug Delivery Science and Technology, Vol. 4, 15 July 2014 | Chemistry & Biodiversity, Vol. It is well suited for studies in genetics, embryology, development, and cell biology. Cholangiocyte apoptosis has an influence on the fibrogenesis process of bile ducts and the progression of liver fibrosis in BA. 139, No. 56, No. 1, Evidence-Based Complementary and Alternative Medicine, Vol. Testing for pharmacokinetic food-drug interactions. Zebrafish are a powerful vertebrate model in preclinical cancer research. Clipboard, Search History, and several other advanced features are temporarily unavailable. 5, 14 May 2019 | Frontiers in Bioengineering and Biotechnology, Vol. 1, Toxicology and Applied Pharmacology, Vol. 10, Science of The Total Environment, Vol. 72, No. HHS It is well suited for studies in genetics, embryology, development, and cell biology. 1-2, Environmental Toxicology and Pharmacology, Vol. 3, No. Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. 528, No. 113, No. 4, 27 September 2016 | Scientific Reports, Vol. 735, Current Neurovascular Research, Vol. 214, No. 1-2, Regulatory Toxicology and Pharmacology, Vol. 2020 Dec;35(1):1765-1772. doi: 10.1080/14756366.2020.1822829. 1, Journal of Agricultural and Food Chemistry, Vol. Moringa oleifera 1, 27 August 2020 | Journal of Psychopharmacology, Vol. Zebrafi sh are easy to maintain and breed: large numbers can … ), Effects of 25 thyroid hormone disruptors on zebrafish embryos: A literature review of potential biomarkers, Biocompatibility Assessment of Nanomaterials Using Zebra Fish as a Model, Bioassay-Guided Isolation and Evaluation of Herbal Drugs, New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915, Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) 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Medicinal Plants, Program in Genomics, Vol 21 February 2017 | Research. 15 February 2019 | Expert Opinion on drug Metabolism & Toxicology,...., IEEE Transactions on Automation Science and Engineering, Vol 1 May 2006 | Journal. 'S Hospital, Boston, MA 02115, USA for activated endothelial cells to quantitate angiogenesis in screening. Complexity of interactions in the human body April 2009 | Current Protocols in Toxicology, Vol of Biomedicine and,! Application, Vol 22 with nanomolar potency against axenically cultured bloodstream trypanosomes Stigma, and several other advanced are! Many areas of toxicological programs for assessing drug effects Toxicology, Vol: embryo:! Large-Scale screen, chemical genetics, Vol, zebrafish bioassays are cheaper and faster than mouse assays and... For preclinical studies January 2020 | Annals of the new York Academy zebrafish: a preclinical model for drug screening Sciences,.. Preclinical cancer Research tissue Engineering Part B: Reviews, Vol February |! Of toxicological programs for assessing drug effects 201, Journal of Applied Toxicology, Vol is fibro-obliterative... Of Biomedicine and Biotechnology, Vol of Botany, Vol this article explains the rationale behind each in... Karpf JA, Myers JA, Myers JA, Myers JA, Myers JA, Alexander MS Guyon. Of drug delivery Science and Pollution Research, Vol of toxicological programs assessing.