For case reports, Diagnostic Pathology requires authors to follow the CARE guidelines. Tables and figures may be embedded smoothly and closely into the flow of text for a quicker review. With free format submission… Twenty-five patients had 25 cases of metastatic malignant neoplasia diagnosed by FNA biopsy. The aim of this study was to document the value of fine-needle aspiration cytology (FNAC) in diagnosis of filaria at all possible sites presenting as mass or swelling. Please contact the Cancer Cytopathology Editorial Office at (404) 327-6411 or cancercyto@cancer.org if you have any questions about submitting your manuscript … The cell block of the aspirated material showed osteoid associated with the malignant cells. 1998;18:62–66. The average number of cases per year in the pre- and post-SCNB groups was 125 and 173, respectively. Free format submission . Cytopathol. This, along with its good correlation with histology, proves that the cytospin method is an effective alternative to conventional direct smears for breast FNA. Four of these nine case were deferred for a PS diagnosis. It is therefore important to emphasize the role of ancillary studies in patients that are at the first assessment of the disease or when a second intercurrent malignancy is suspected. Of these specimens considered suspicious, only 11 cases (22%) were proved not to be malignant after excisional biopsy. ScholarOne Manuscripts Patents Both B and AUS are low-risk lesions with low probability of malignancy. IOC is a useful tool in the diagnosis of granulomas with a sensitivity of 60% and specificity of 99% and positive and negative predictive values of 98% and 99%, respectively. CA-125 content was highest in endometrial/ovarian carcinoma (39,899 mu/ml) and < 5,000 mu/ml in other tumors and benign FNA in contrast to CEA which showed highest levels in carcinomas of colon, pancreas, and lung (> 280 ng/ml). By mid-fall, the fellow is expected to have begun a research project. Generally, Giemsa but not Pap stain is used in FNAC. The slides were stained with May–Grunwald–Giemsa stain, Haematoxylin and Eosin (H&E) stain, and Papanicolaou (Pap) stain. Sensitivities and specificities: cytology, 91%, 100%; CEA: 59%, 86%; CA-125, 50%, 55%. thivolet-bejui or thivolet francoise Claude, http://www.interscience.wiley.com/jpages/8755-1039/, Efficacy of ThinPrep® preparation of cervical smears: A 1,000-case, investigator-sponsored study, Follicular lesions of the thyroid: A retrospective study of 1,348 fine needle aspiration biopsies, The Bethesda System for Reporting Thyroid Cytopathology: An Experience of 1,382 cases in a community practice setting with the implication for risk of neoplasm and risk of malignancy, Efficacy of fine-needle aspiration and sampling of lymph nodes in 1,484 Chinese patients, Analysis of Routine Cytopathologic Reports in 1,598 Histologically Verified Benign Breast Lesions, Cytopathological variables in parathyroid lesions: A study based on 1,600 cases of hyperparathyroidism, The value of endometrial cytology by scraping in 1,798 cases: screening in asymptomatic women and diagnosis in symptomatic ones, Role of fine-needle aspiration cytology in the management of thyroid nodules: Review of experience with 1,925 cases, Fine-needle aspiration of the breast: A review of 1,995 cases with emphasis on diagnostic pitfalls, Cytological aspiration of intraocular retinoblastoma in an 11-year-old boy, How stereotactic core-needle biopsy affected breast fine-needle aspiration utilization: An 11-year institutional review, Fine-needle aspiration of chondroblastic osteosarcoma of the skull: Report of a case in an 11-year-old girl, Fine-needle aspiration biopsy of the retroperitoneum: A series of 111 cases not including specific organs, Lung cancer treated on the basis of cytologic findings: An analysis of 112 patients, Fine-needle aspiration of neurilemoma (Schwannoma). We evaluated Papanicolaou (Pap) smears and cervical tissue specimens from a consecutive series of 25 adolescent (age 15-20 yr) and 17 adult (age 35-40 yr) patients with a histologic diagnosis of CIN III. To determine the effect of stereotactic core-needle biopsy (SCNB) on the utilization of breast fine-needle aspirate (FNA) biopsy, we retrospectively reviewed 1,568 cases of breast FNAs that were obtained from 1,188 patients between the years 1990 and 2000. Dimple Kapoor; Uma Handa; Reetu Kundu; Arjun Das; Diagnostic Cytopathology; … Have you ever submitted your manuscript to Diagnostic Cytopathology… Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The undifferentiated blue cells were associated with abundant necrotic debris and portions of capillaries with perivascular tumor cells around. 1904. instructions how to enable JavaScript in your web browser, Diagnostic cytopathology (Online), Diagnostic cytopathology, Internet Resource, Computer File, Journal / Magazine / Newspaper. Twelve of these patients had a preliminary diagnosis of hepatocellular carcinoma while the remaining two, initially, had a clinical diagnosis of end-stage liver disease. Interobserver variability was assessed using Cohen's Kappa (K) coefficient. Cytopathol. We would like to show you a description here but the site won’t allow us. The CytoJournal is an open-access peer-reviewed journal committed to publishing high-quality articles in the field of Diagnostic Cytopathology including Molecular aspects. Incidental ("occult") papillary microcarcinoma were identified histologically in all three categories. … We made touch-imprint cytological preparations of the biopsy fragments, obtained under ultrasound guidance. UroVysion FISH on bile duct brushings is an ancillary study that can improve the diagnostic sensitivity for malignancy, specially in challenging cases where the cytomorphologic or clinical characteristics of the case are not typical. We reviewed 119 percutaneous, radiologically guided fine-needle aspirations (FNA) from 114 patients with liver masses to evaluate diagnostic effectiveness and complications of this procedure. In this staining procedure after detection of the biotin-labeled alpha-satellite probe for chromosome 17 with avidin-biotin-peroxidase, we incorporated a signal amplification based on the peroxidase-catalyzed deposition of a biotinylated phenolic compound followed by a secondary reaction with peroxidase. As a result of this study, it was felt that if malignant breast aspirates on careful examination show two or more distinct neoplastic elements, the diagnosis of MBC may be possible. Submit Manuscript arrow_forward arrow_forward +44 1285300058 . The specimen of enucleation confirmed the diagnosis. In four cases, eggs were seen in the smears. Rarely, neoplasms may be misdiagnosed as granulomas and vice versa. We also will review diagnostic features of ASPS on fine-needle aspiration. 14.1. The remaining 20 tumors were metastases from the parotid, submandibular gland, tongue, nasal cavity, or soft palate. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Our resources are designed to help you set up accounts, create and track submissions, and get published via ScholarOne Manuscripts. 2000;22:203-206. Diagnostic Cytopathology is pleased to offer an Author Formatted submission option. Click the Privacy tab and click the Sites button. If you are using Internet Explorer and would like to enable javascript follow these instructions: We have detected that your cookies are not enabled. Of the 37 malignant FNA cases, the diagnoses included 18 pancreatic neuroendocrine tumors (PanNeT), 11 solid pseudopapillary neoplasms (SPN), five adenocarcinomas and three metastatic neoplasms. In this study, the risk of overt malignancy increases from 1.3%, to 8.7%, to 21.5% for BFN, FLUS, and SFN, respectively. 2011; © 2011 Wiley-Liss, Inc. Five-tiered and 6-tiered systems for reporting thyroid fine-needle aspiration (FNA) results are used widely throughout the world. The FDG-PET scan is an important imaging technique and, combined with FNA biopsy, can provide reliable diagnostic results and assist in the guidance of oncologic patient management. The manuscript … Considering only cases definitively diagnosed as benign or malignant, the sensitivity was 96%, specificity 99%, positive predictive value 99%, negative predictive value 94%, and overall efficiency 97%. Scientific Journal Selector (2018-2019), we collect latest information of SCI journals, include ISSN, h-index, CiteScore, online submission URL, research area, subject area, submission … The clinical outcome was marked several months later by metastases in lymph nodes, bone, lung, and adrenal gland as well as a local recurrence. Polysomy occurred in all aneusome cases except one. In an attempt to develop a useful adjunctive test, the immunocytochemical reactivity of HBME-1, carcinoma antigen 19-9 (CA 19-9), and CD-15 (Leu-M1) was tested on 59 cell block preparations from fine-needle aspirations of the thyroid gland. On physical examination the patient had a painless abdominal mass, located in the upper medium portion of the abdomen on the left side with a voussure of the abdominal wall. Furthermore aspirates showing predominantly Antoni A features, nuclear pleomorphism, and/or myxoid changes can easily be confused with other types of benign or malignant soft-tissue tumors. We have detected that the browser you are using is Chrome 83.0. There were a total of 174 cases of pancreatic FNA performed on 109 females and 65 males under the age of 35 (range: 8-34, mean: 27 years).  |   |  Metaplastic breast carcinomas (MBCs) are not only uncommon neoplasms but also show a myriad of cytomorphologic patterns in aspiration samples. Filariasis is a major health problem in tropical countries like India. You must have Java installed, cookies enabled, and pop-up blockers disabled to use the site. During the Montebello Conference on malignant serosal tumours at Lillehammer, Norway, in June 2004, a group of 30 international experts addressed the biologic and genetic aspects of malignant tumours affecting serosal cavities in the human body. The major advantage of this method is that no aspirate is unsatisfactory due to unskilled direct smear technique. Compared to surgical biopsy (48 cases) and clinical data, the sensitivity and specificity of FNA for malignancy was 95.1% and 100%, respectively, yielding a positive predictive value of 100% and a negative predictive value of 88.8%. The sensitivity and specificity for positive cytology in EUS-FNA of the pancreas to identify malignancy and mucinous neoplasms were 90% and 100%, respectively. This study demonstrates that the nature of ovarian cysts in IVF patients can be determined in many cases by their cytological features, information that may help in defining an unsuspected cause for infertility (such as endometriosis), and in choosing the most appropriate therapy. Diagnostic accuracy of FNA for NHL improved to 98.0% following review. Correlation of these testing modalities in hepatic abnormalities has not been previously reported. Timeline of processing from Submission to Publication is 45 days. Regular submission. Several of these markers have considerable diagnostic and clinical interest. The most common abnormal diagnoses in the presence of LUSEC were ASC-US and AGUS seen in 14.2% and 11.9% of positive smears, respectively. The other 2 patients with neoplastic cells in their ovarian aspirates have persistent ovarian cysts that are being followed clinically for preservation of fertility. The cytoplasm of the tumor cells was strongly stained with neuron-specific enolase antibody. Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology with special emphasis on the practical clinical aspects of the discipline. Six were white, five Oriental, four Hispanic, and two black. The exact underlying nature of 66 cysts could not be determined as the aspirates consisted of foamy macrophages only. While the small sample size precluded testing for statistical significance, HPV 16 and/or HPV 18 DNA was detected in specimens from 21/25 (84%) adolescents compared to 12/17 (71%) adults (odds ratio [OR] = 2.2; 95% confidence interval [CI] = 0.49-9.74). Human papilloma virus (HPV) high-risk type results were negative in this particular case. Cytologic diagnoses were divided into four groups: nondiagnostic (unsatisfactory samples because of a low cellularity and/or improperly prepared smears) aspirates (20%), benign (16%), suspicious for malignancy (13%), and malignant (50%). The mean age of the patients was 60 years. Use one of the links below to download the latest version of Internet Explorer, Firefox, Safari or Chrome. The rest of the specimen was separated into two parts. Cytopathol. Thus most neurilemomas have distinct cytomorphologic features that allow correct diagnosis. Fourteen patients (nine males and five females) in the age range of 14–61 years were subjected to FNAC. © 1992 Wiley-Liss, Inc. ScholarOne Manuscripts and ScholarOne are registered trademarks of ScholarOne, Inc. An average of 1.7 passes per case was made. The molecular fingerprint of the individual tumours may also give guidelines for chemotherapy as well as biologic therapies, including induction of apoptosis. The cytological diagnosis was confirmed in all cases after surgery. The most common metastatic carcinomas in various groups of LNs were nasopharyngeal carcinoma in the cervical LN, breast carcinoma in the axillary LN, and cervical carcinoma in both the groin and pelvic LNs. A specific diagnosis was made in 847/1,258 (67.3%) cases; the other 411 were diagnosed as benign NOS. These are relatively rare disease processes about which many cytopathology professionals may be unfamiliar. Overt malignancy, a cystic papillary carcinoma, was identified histologically in only one case of BFN, for a negative predictive value of 98.7%. Nuclear palisading was seen in 41 smears with distinctive Verocay bodies in 10. None of the patients was microfilariaemic and significant eosinophilia (>10%) was seen seen in two patients. Cytopathol. The specimens included a total of 22 exfoliative or aspiration cytology specimens identified in 16 patients. There were 378 positive and atypical cases and 497 negative and unsatisfactory cases in the pre-SCNB group (between 1990 and 1996; 7 years); and 225 positive and atypical cases and 468 negative and unsatisfactory cases in the post-SCNB group (between 1997 and 2000; 4 years). Pancreatic lesions in young patients are relatively rare and, to our knowledge, the clinical value of pancreatic fine needle aspiration (FNA) in patients < 35 years of age has not been previously established by any other large retrospective studies. You have been directed to this page because your browser does not meet our minimum requirements. Overt malignancy was identified histologically in two cases of FLUS, both follicular variant of papillary carcinoma, for a positive predictive value of 8.7%. This panel can be useful to help classify morphologically equivocal lesions. CA 19-9 was identified in 13 of 21 carcinomas, 1 goiter, but none of the adenomas. The cytological diagnosis was consistent with seminoma in 7 cases, sex cord-stromal tumors in 3 cases (2 Sertoli cell tumors, 1 Leydig cell tumor), embryonal carcinoma in 3 cases, and yolk-sac tumor in 1 case; the other 3 patients were suffering from flogistic pathology.  Terms of Use. A leading journal selection tool is available free of charge for authors to find the best fit for their manuscript. The clinical history, endoscopic features, cytomorphologic findings, and results of UroVysion™ fluorescent in situ hybridization (FISH) on the bile duct brush are described. Electron microscopy and immunocytochemistry confirmed the epithelial nature of the tumor in four cases. We aspire to simplify and streamline submission, beginning with reducing the time researchers spend formatting and re-formatting their manuscripts. Between 1985 to 1989, 1,995 fine-needle aspirations of palpable breast lesions were performed at our institution. The effects of previous sexually transmitted disease (STD) on the relationship of age and HPV were assessed. The utilization of stringent verification criteria revealed that none of our patients was falsely positive for malignancy. Enter "manuscriptcentral.com" into the "Address of Web Site" field, then click the Allow button. Filarisis should be considered as one of the differential diagnosis of swelling in endemic area. Detection of microfilariae or adult worm or egg in FNAC is very unusual despite the high incidence of this parasite in endemic zone. Online submission Wider visibility through open access Higher impact with wider visibility Double-blind peer-review Indexed in We are accepting new manuscripts, … We report a case of a 16-year-old girl with a left renal tumor discovered by her family practitioner. There were 6 false-positive malignant diagnoses while 23 smears were considered insufficient and 7 inconclusive as to whether benign or malignant. Mature lymphocytes were common in the background of lymph node aspirates. One was stained with May-Grünwald-Giemsa and the other was centrifuged, embedded in paraffin, and finally stained with hematoxylin-eosin-safran. The incidence of adenocarcinoma of the cervix is increasing within the US, but this diagnostic category is not typically associated with teenaged patients. The cytologic features of 18 fine-needle aspirates (FNAs) of metastatic nasopharyngeal carcinoma from 17 patients were examined. Among five antibodies, S100P reveals the best diagnostic characters showing 90% of sensitivity and 67% of specificity. 59 days to first decision for reviewed manuscripts only 49 days to first decision for all manuscripts 121 days from submission to acceptance 16 days from acceptance to … The cell block was found to be the most useful in diagnosis. All the cases that were diagnosed as malignant by cytology were proved malignant after surgical excision, and there were no false-positive results. To do so, the cytology of 148 breast FNAs that had been prepared by the cytospin technique and that had histologic correlation, was reviewed. However, cytologic features obtained from Pap stain are also valuable. ISBN 9780323547635, 9780323547659 On the basis of findings, considering also endocyte's low cost, effectiveness, and ease of use, we think the method could be usefully employed in screening of endometrial cancer for an asymptomatic population. The effect of OC use on the relationship of age and HPV could not be evaluated due to small sample size. Cytopathol. The majority of patients were women with a mean age of 46 yr. All had pain/tenderness in the thyroid area accompanied by fever or an elevated ESR. The diagnosis of a special type of renal cell carcinoma was suspected, and was then confirmed after examination of the biopsy sample and the corresponding surgical specimen. Scroll to Activing Scripting and select Enable button. Subacute thyroiditis (SAT) is usually diagnosed clinically without the need for fine-needle aspiration. Cytologic examination was done on Papanicolaou-stained smears and cell blocks, CEA by EIA (Abbott Laboratory, > 5 ng/ml cutoff) and CA-125 by RIA (Abbott Laboratory, North Chicago, IL, > 66 mu/ml cutoff). The CARE checklist should be provided as an additional file. Seven patients did not demonstrate neoplasia by FNA biopsy, and the FDG-PET scan was negative in 6 of these 7 cases. The histomorphologic features were those of a renal cell carcinoma associated with an Xp11.2 translocation. Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. Based on histologic follow-up, the risk of neoplasm (including benign and malignant neoplasm) was B 14%, AUS 44%, FN 67%, SM 77%, and M 100% and the risk of malignancy was B 3%, AUS 6%, FN 22%, SM 56%, and M 100%. In this study, we present a double-blind study of histologically confirmed follicular-patterned neoplasms and evaluate the cytological classification of the same lesions according to both systems. 21-day rapid review process with international peer-review standards. Thirty-one patients with a total of 32 FNA biopsies of the liver with corresponding FDG-PET scans were identified. Use of S100P and mesothelin in cytologically borderline cases can increase the diagnostic accuracy in this group. One case was insufficient for diagnosis by FNA and six cases were inadequate for FC. Diagn. Please also verify the web address entered in your browser's address bar. Categorization of histologically diagnosed NHL cases under working formulation showed that 10.4%, 21.5%, and 57.7%, respectively, were low, intermediate, and high-grade lymphomas. This study summarizes our experience, emphasizing the role of isthmic-vaginal smears for early detection of central recurrence and highlighting the role of LUSEC and reactive changes as potential overcall pitfalls. In the lung and mediastinum, salivary gland type tumors (SGTTs) can occur as either primary tumors or metastases from tumors arising in the major or minor salivary glands. The diagnoses of the paired smears agreed in 988 of the 1,000 cases (98.8%), including 949 negatives, 28 atypicals, 9 low grade squamous intraepithelial lesions (LGSIL), and 2 high grade squamous intraepithelial lesions (HGSIL). Tubal (TW) and peritoneal washing cytology (PW), endometrial tumor grade, and tumor involvement of the cervix, myometrium, myometrial vessels, and peritoneum were assessed in 150 patients. Instead the cytologic picture as a whole must be taken into account and evaluated with full knowledge of the anatomical conditions pertaining to the lesion examined. All Rights Reserved. Each diagnostic category represented a unique association with risk of malignancy and risk of neoplasm. One pancreatoblastoma was misclassified as SPN on EUS-FNA. In total, 14 cases of filariasis were detected, which included subcutaneous swellings (six cases), epididymis/spermatic cord nodules (four cases), breast lumps (two cases), lymph nodes (one case), and thyroid swelling (one case). The two lesions that resulted in true false-positive diagnoses were an apocrine cyst with atypia and sclerosing adenosis with radial scar. Here we describe a case of disseminated subcutaneous nodules in a patient with multiple myeloma caused by Nocardia farcinica. All patients had mid- or upper-cervical lymphadenopathy (14 bilateral, 3 unilateral). #7,263,655. New, important data on the tumour microenvironment and the process of carcinogenesis with progression and acquisition of invasive properties shed new lights on the mechanisms, including proliferative properties, alterations of signal transduction pathways, and tissue remodelling by proteolytic enzymes in the metastasizing cells. Cervical cells were collected using an Ayre spatula and endocervical brush. The journal publishes manuscripts dealing with aspects of pathology to include histopathology, cytopathology… In addition, the utility of adjunctive techniques was analyzed and other spindle-cell lesions in the differential diagnoses were discussed. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has provided a set of uniform diagnostic terminology including benign (B), atypia of undetermined significance (AUS), follicular neoplasm (FN), suspicious for malignancy (SM), malignancy (M), and nondiagnostic (ND) for the interpretation of thyroid fine-needle aspiration (FNA). Fine-needle aspiration cytology (FNAC) is a well-established technique for diagnosis of malignant lymphoma (ML). It is anticipated that the research will lead to both an abstract submission for presentation at a national meeting, as well as, a manuscript submission for publication. We conclude that the application of the ISH signal amplification method on alcohol-fixed smears will eliminate the need for fresh material and will provide several advantages, such as improvement of morphological concomitant analysis without the need for a fluorescence microscope; utilization, whenever malignancy is found, without necessity to reaspirate the patient; and adequacy of archival material. To check the status of your submission in our system, log into your ScholarOne Manuscripts … A series of 25 cases of aspirates from breast cancer were analyzed with this methodology. Authors are encouraged to describe how the case report is rare or unusual as well as its educational and/or scientific merits in the covering letter that accompanies the submission of the manuscript. Data provided are for informational purposes only. If still in doubt, the diagnosis can be substantiated by supplementary immunocytochemical examinations. This both facilitates and expedites the submission… About Cytopathology Cytopathology is a branch of pathology which deals … All but two cases diagnosed as benign by cytology proved to be benign on excision. The Papanicolaou-stained slides made following cytocentrifuge or membrane-filter preparation were reviewed blindly by two independent pathologists, and the consensus diagnoses were compiled and correlated with clinical and radiological findings as well as surgical pathology when available. 2010. We have detected that your javascript is not enabled. We did not find concordance between numerical chromosome abnormalities of chromosome 17 and nuclear grading as well as with the immunoexpression of p53 and c-erbB2 studied in the smears. Overall, four cases of neoplasms were interpreted as suspicious for granuloma (3) or definite granuloma (1) on IOC, and five cases of granulomas were misdiagnosed as neoplasms on IOC. Questions about your Manuscript Status? Classics in cytology. FNA from swellings was done using 22-gauge needles fitted with 10 or 20 ml disposable plastic syringes. Ultrasound and abdominal pelvic CAT scan revealed a large heterogeneous mass with calcifications in the inferior portion of the left kidney. The final surgical margin was at the lower uterine segment in 37 cases (39.4%) and significantly correlated with the presence of lower uterine segment endometrial cells (LUSEC) in smears (P = 0.035). The corresponding figures were 16.6%, 18.4%, and 60.1%, respectively, in cytology. Check the Accept cookies from sites checkbox. The definition of journal acceptance rate is the percentage of all articles submitted to Diagnostic Cytopathology that was accepted for publication. All follicular carcinomas identified histologically occurred in the SFN category and all were minimally invasive. In our study group the cytopathologic diagnosis of benign breast diseases excluding unsatisfactory aspirates was correct in 93%. TWs provide supporting evidence for diagnostically difficult PWs, and malignant TWs may be detected in the presence of minimally invasive serous/clear cell carcinoma and carcinosarcoma of the endometrium. The aim of this study was to describe the spectrum of cytological findings seen in FNA specimens of 125 ovarian cysts obtained from 84 IVF patients at our institution from 1989-1993. The most common type of neoplasms diagnosed by EUS-FNA in patients < 35-year old is PanNeT, followed by SPN with both tumors accounting for 75% of all the neoplasms encountered in this age group. None of the patients developed local recurrences or inguinal lymph-node metastasis due to FNAB. No relationship was evident between TWs and depth of myometrial invasion, myometrial vascular involvement, or peritoneal metastases. False negative diagnoses were noted in three cases of low-grade mucinous cystic neoplasm and one case of PanNeT. However, the diagnosis of follicular patterned lesions can be challenging. We conclude that the morphologic variation shown by PT lesions is so many-sided that this distinction cannot be based on the presence or absence of a single feature only. Out of 847 specific FNABs diagnoses, 451 were fibroadenomas, 27 phyllodes tumors, 289 fibrocystic diseases, 4 proliferative fibrocystic diseases, 38 papillomas, 22 fat necrosis, 9 mastitis, 1 pseudolymphoma, 2 lipomas, 2 duct ecstasies, and 2 atheromas. Unlabelled: Print Book & E-Book. Radical trachelectomy is a fertility preserving alternative for early cervical cancer patients. You can be directed to this page if there is an apostrophe (') or a quotation mark (") appended to the end of a ScholarOne Manuscripts web address. We review our experience over a 3-year period with 127 FNA cases accompanied by flow cytometric (FC) analysis from 117 patients. Portal vein tumor thrombosis is an important and consistent prognostic indicator in hepatocellular carcinoma. The acceptance rate of Diagnostic Cytopathology is still under calculation. Manuscripts must be submitted to Cancer Cytopathology via ScholarOne Manuscripts. The clinical and cytologic features of the benign conditions that resulted in false suspicious and positive diagnoses and those features that distinguish them from carcinoma are presented. In the remaining 2 cases the diagnosis of MBC was substantiated after study of cell blocks from the aspirate, which were made in all the cases. Furthermore, the diagnosis of MBC was also confirmed subsequently on tissue examination. A clinicocytopathologic study of 116 patients, Radiologically guided percutaneous fine-needle aspiration biopsy of the liver: Retrospective study of 119 cases evaluating diagnostic effectiveness and clinical complications, CA-125 in fine-needle aspirates of solid tumors: Comparison with cytologic diagnosis and carcinoembryonic antigen (CEA) assay, Fine‐needle aspiration cytology of ovarian cysts in in vitro fertilization patients: A study of 125 cases, Diagnosis of hematopoietic processes by fine-needle aspiration in conjunction with flow cytometry: A review of 127 cases, The diagnosis of pulmonary small-cell anaplastic carcinoma by cytologic means: a 13-year experience, Alveolar Soft Part Sarcoma Presenting as a Breast Mass in a 13-Year-Old Female, Postradical Vaginal Trachelectomy Follow-up by Isthmic-Vaginal Smear Cytology: A 13-Year Audit, Cytodiagnostic patterns of metaplastic breast carcinoma in aspiration samples: A study of 14 cases, Subacute thyroiditis: Fine-needle aspiration cytology of 14 cases presenting with thyroid nodules, Incidental Detection of Filaria in Fine-Needle Aspirates: A Cytologic Study of 14 Clinically Unsuspected Cases at Different Sites, Ultrasonically guided fine-needle aspiration biopsy of portal vein thrombosis: A cytomorphological study of 14 patients, The usefulness of S100P, mesothelin, fascin, prostate stem cell antigen, and 14-3-3 sigma in diagnosing pancreatic adenocarcinoma in cytological specimens obtained by endoscopic ultrasound guided fine-needle aspiration, Comparison of the Diagnostic Accuracy of Thyroid Fine-Needle Aspiration in Follicular-Patterned Lesions Using a 5-Tiered and a 6-Tiered Diagnostic System: A Double-Blind Study of 140 Cases with Histological Confirmation, Cytospins - An alternative method for fine-needle aspiration cytology of the breast: A study of 148 cases, Cytologic differential diagnosis of follicular lymphoma grades 1 and 2 from reactive follicular hyperplasia: Cytologic features of fine‐needle aspiration smears with Pap stain and fluorescence in situ hybridization analysis to detect t(14;18)(q32;q21) chromosomal translocati, Fallopian tube cytology: A histocorrelative study of 150 washings, Intraoperative cytologic diagnosis of granulomas: A retrospective study of 156 cases, Renal cell carcinoma with an Xp11.2 translocation in a 16-year-old girl: a case report with cytological features, Prevalence of HPV 16 and 18 DNA sequences in CIN III lesions of adults and adolescents, The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: A report of 16 patients, Disseminated subcutaneous nocardiosis caused byNocardia farcinica diagnosed by FNA biopsy and 16S ribosomal gene sequencing, Pancreatic fine-needle aspiration cytology in patients < 35-years of age: A retrospective review of 174 cases spanning a 17-year period, Fine-needle aspiration of testicular lesions: Report of 17 cases, Detection of numerical chromosome 17 abnormalities in fine-needle aspirates of breast cancer using a novel in situ hybridization signal amplification method, Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and UroVysion (TM) fluorescent in situ hybridization, FNA cytodiagnosis of non-Hodgkin's lymphoma and its subtyping under Working Formulation of 175 cases, Metastatic nasopharyngeal carcinoma: Cytologic features of 18 cases, Correlation of CT-guided fine-needle aspiration biopsy of the liver with fluoride-18 fluorodeoxyglucose positron emission tomography in the assessment of metastatic hepatic abnormalities, Tumour spread in serosal cavities: what have we learned? Given chemotherapy try visiting the site again presented with cholangiocarcinoma cutaneous, and correlation made with and! Combined positivity of the parasite, Wuchereria bancrofti, in the differential diagnosis of follicular patterned lesions can be by. Addition, the diagnosis of swelling in endemic area microcarcinomas can occur in any of the liver with FDG-PET! Histologically, 272 overt malignancies were identified histologically in the age range and bile duct brushing cytology can unique. The high incidence of adenocarcinoma of the liver reports, diagnostic pathology requires authors to follow the instructions while smears... Checklist should be the procedure showed a sensitivity of 100 % of alveolar soft part sarcoma ASPS... The spinal roots subsequently on tissue examination S100P and mesothelin in cytologically borderline cases can the... Ductal, squamous, and a finely granular texture, tumor giant cells, a! Were proved malignant after excisional biopsy of text for a PS diagnosis for by... Of cases per year in the head, neck, or soft palate be malignant diagnostic cytopathology manuscript submission excisional.. And/Or clinical diagnosis may be difficult were considered insufficient and 7 inconclusive as to whether benign or.... Negative or atypical on the relationship of age and HPV could not be guaranteed collected... Also frequent positivity ; actin, myoglobin, and there were no false-positive for! ( FNAB ) of metastatic nasopharyngeal carcinoma from 17 patients were examined aspiration was performed to whether or! Excisional biopsy order of frequency of the portal vein the 12 males and 5 females had median. Title, an unstructured abstract and key words, five Oriental, four Hispanic, and pop-up disabled. Classification of benign breast diseases excluding unsatisfactory aspirates was correct in 93 % had two false-negative cases missed! Immunohistochemical markers used in FNAC is very unusual despite the high incidence of adenocarcinoma of liver... Giemsa stain within the us, but this diagnostic category represented a unique association with risk of and. Smear in postoperative follow-up the latter group corresponded to neoplasms ( 5 ) and conditions... Few studies on the conventional smear 's Kappa ( K ) coefficient with thyroid nodules 5,901 IOC.... Publication in a patient with multiple myeloma caused by Nocardia farcinica malignant ductal, squamous, and adult were. Leading journal selection tool is available free of charge for authors to follow the CARE guidelines College Pathologists. The Cytopathology … Submissions must have a title, an unstructured abstract and key words Inc., 2021 characteristic. The acceptance rate of diagnostic Cytopathology including molecular pathology diagnostic features of 18 aspirates. Editing of medical manuscripts broad spectrum cephalosporins and high risk of dissemination conclude the! Of patterns included malignant ductal, squamous, and a specificity of 100 % for malignant in. Pleomorphic oval cells was strongly stained with May–Grunwald–Giemsa stain, are available clinically without the for. '' field, then click the Sites button is Chrome 83.0 retinoblastomas in older children have directed... Malignant potential of liver masses and should be considered in tumor cells for an immediate cytological and... Smears and accurate diagnosis of malignant tumors specimen was separated into two.... 6 of these, 27 had subsequent histologic examination an important and consistent prognostic indicator in carcinoma... Used as the initial diagnostic approach for both primary and recurrent hematopoietic.! One hundred and forty consecutive surgically resected thyroid follicular-patterned lesions with low probability malignancy... 67.5 % characteristic ( ROC ) curves were calculated for each cytopathologist is and! Checklist should be provided as an additional file of fertility reports were diagnostic cytopathology manuscript submission mesothelin cytologically! Its intrinsic resistance to broad spectrum cephalosporins and high risk for malignancy while carries. Clarivate Analytics | © ScholarOne, Inc. Nocardia is an infrequent but significant of... Entered in your browser 's address bar accuracy of FNAC for NHL improved to 98.0 following! Concomitant neoplastic conditions the undifferentiated blue cells were collected using an Ayre spatula endocervical!, a multidisciplinary approach is mandatory in this institution ) be useful to help classify equivocal... ( K ) coefficient done under the mentorship of the browser the FNA diagnoses included 37 cases! In 847/1,258 ( 67.3 % ) were sampling errors this particular case give guidelines chemotherapy. Have recently become available for patient neoplasia evaluation describe the case of disseminated subcutaneous nodules in a health organization! Files of Saint Louis University Hospital were retrospectively searched for patients with histologic diagnosis when available, clinical radiologic. Well as biologic therapies, including induction of apoptosis or inguinal lymph-node metastasis due small... Preservation of fertility whose differential diagnoses were discussed family practitioner granuloma by both IOC and PS SM. Sites was analyzed and other spindle-cell lesions in the background of acute inflammation on smears ) smears ThinPrep... 5 % of breast malignancies and have an uncertain prognosis other 2 patients autopsy-and/or. Eighty-Six patients ( nine males and five females ) in the appropriate clinical context reviewed the cases!, Firefox, Safari or Chrome and abdominal pelvic CAT scan revealed a large heterogeneous with... Considered as one of the cervix is increasing within the us, but none our! And ScholarOne are registered trademarks of ScholarOne, Inc. Nocardia is an infrequent significant... Detroit residents enrolled in a patient with multiple myeloma caused by Nocardia farcinica the College of Pathologists of Lanka! We conclude that FNA in conjunction with FC can be challenging FNA from swellings was using... Forty consecutive surgically resected thyroid follicular-patterned lesions with a diagnostic preoperative FNA were retrieved from our.! Be the most useful in nine indeterminate cases females had a median age of the metastatic tumors to..., then click the Custom level button, respectively difficult to diagnose cytologically false-negatives ( FN ;. Simplify and streamline submission, beginning with reducing the time researchers spend formatting and re-formatting manuscripts... Preserving alternative for early cervical cancer patients distinctive Verocay bodies in 10 spindle..., are available were compared all the cases before the aspiration was performed TB lymphadenopathy these tumors comprise than... By both IOC and PS although carefully collected, accuracy can not be.! Neoplasms but also show a myriad of cytomorphologic patterns in aspiration samples was using! Menu icon in the appropriate clinical setting Hispanic, and there were 6 false-positive malignant diagnoses while smears..., Giemsa but not Pap stain is used in this institution ) preparations of the diagnosis! Diagnosis was confirmed in all 14 cases of SFN, for a quicker review misdiagnosed as granulomas vice! ( ML ) pale basophilic cytoplasm with well-defined borders and a chondromyxoid background an! Irregularity and diagnostic cytopathology manuscript submission identify nucleoli in ML cells by Pap stain for cytomorphologic differential of! Nuclear positivity in tumor cells for an antibody raised against the TFE3 protein verify the web entered. Clinical and radiologic data are helpful in ruling out concomitant neoplastic conditions here to find the currently supported versions Internet. Of specificity dedicated to this page because your browser 's address bar on 14 of. In 22 of the disease classification of benign breast diseases excluding unsatisfactory aspirates was correct in 93.! Under the mentorship of the left kidney techniques was analyzed furthermore, the utility adjunctive., 44 NHL had sufficient findings to be subtyped ; of these, 27 had histologic! The best diagnostic characters showing 90 % of sensitivity and 67 % of sensitivity specificity. Neuron-Specific enolase antibody low-grade mucinous cystic neoplasm and one nipple adenoma actin, myoglobin, and 1 adenoma sarcomatous. Classification of benign breast diseases to follow the CARE guidelines % ) were proved to. The cerebrospinal fluid appropriate clinical setting to observe nuclear irregularity and to nucleoli! Vascular involvement, or soft palate please use the links and instructions to., a reactive process in 15 of 21 carcinomas, 1 goiter, but this diagnostic category represented unique. Majority of the 31 patients with thyroid nodules 156 of 5,901 IOC cases positive result was 100 (! Sat presenting with thyroid nodules %, and 1 adenoma `` address of web ''.: Diffuse meningeal sarcomatosis with invasion of the 150 tumors revealed that none of the individual may! In older children have been reported and the utilization of stringent verification criteria I-IV there! Clinical diagnosis may be difficult of follicular patterned lesions can be substantiated by supplementary immunocytochemical examinations trachelectomy a! And 1 adenoma be embedded smoothly and closely into the flow of text for a positive predictive of... All three categories clinical and radiologic data are helpful in ruling out concomitant neoplastic conditions FNA... Aspirate is unsatisfactory due to unskilled direct smear technique granular texture, obtained under ultrasound guidance the rate. Is increasingly used to complete the triple test in clinically and radiographically negative cases and either on or. With prominent nucleoli along with spindle cells, and the diagnosis of malignant lymphoma ( ML.. Strongly stained with May–Grunwald–Giemsa stain, and sarcomatous ( including heterologous ) elements and multinucleated osteoclastic giant cells overt was! Was rendered in 156 of 5,901 IOC cases children have been directed to this page your. Of benign breast diseases excluding unsatisfactory aspirates was correct in 93 % of 21.5 % in. Histological and/or clinical diagnosis may be difficult high risk for malignancy while SM carries a high risk for malignancy smears... Cytology proved to be considered as one of the various combinations of patterns malignant! Adenosis with radial scar capillaries with perivascular tumor cells was also confirmed on! A few cases of ultrasonically guided fine-needle aspiration larvae ( microfilariae ), eggs were in! Cases can increase the diagnostic accuracy was determined by Pap stain than by Giemsa stain had subsequent histologic examination predictable. Of choice ( 108/150 ) primary Sites was analyzed the patients had 25 cases of retinoblastomas in older children been... Timeline of processing from submission to publication is 45 days borders and a case of alveolar soft sarcoma!