Arthritis Rheum 2007;56(7):2267-2277. 2005 - 2023 WebMD LLC. Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. 2010;21(12):1993-2002. Nonvertebral fracture benefit from oral ibandronate administered daily or with a unique drug-free interval: Results from a pivotal phase III study in postmenopausal osteoporosis (PMO). Gedalia, I., Brayer, L., Kalter, N., Richter, M., and Stabholz, A. [No authors listed]. I found that Strontium is eliminated by the kidneys and can build up in people with poor kidney function. Ringe, J. D. and Doherty, J. G. Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat. A. Hyaluronic acid injections relieve knee pain. American Bone Health4208 Six Forks RoadSuite 1000Raleigh, NC 27609. It does not recommend it as a treatment for anyonewho has or has had heart or circulatory problems such as stroke, heart attack, or obstruction of the blood flow in the arteries. View abstract. J Clin.Dent. This is more important for postmenopausal women. Strontium ranelate for preventing and treating postmenopausal osteoporosis. 2010;21(4):667-677. Clin Sci 1968;34:351-63. View abstract. It is an alkaline earth metalmost similar to barium and calcium. Hello @bonelady welcome to Connect. Review of clinical studies. Strontium and calcium metabolism. I. Inhibition of intestinal calcium absorption and 1,25-dihydroxycholecalciferol synthesis. View abstract. Overall, the review concludes: For patients with castration-resistant prostate cancer suffering from malignant bone pain, treatment with a bone-seeking radiopharmaceutical is a relevant therapeutic option often resulting in significant pain reduction. A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. Supplements are increasingly available over the counter and through the Internet. Ann Intern Med 2007;146:580-90. View abstract. (3). Bruyere, O., Delferriere, D., Roux, C., Wark, J. D., Spector, T., Devogelaer, J. P., Brixen, K., Adami, S., Fechtenbaum, J., Kolta, S., and Reginster, J. Y. Strontium as a marker for intestinal calcium absorption: the stimulatory effect of calcitriol. View abstract. Stable strontiums atomic symbol is Sr, its atomic number is 38 and its atomic weight is 87.62. 2006;54(11):3494-3507. J Bone Miner Res 1999;14:1789-95. A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer. McAlindon TE, LaValley MP, Gulin JP, Felson DT. View abstract. It seems to play a role in how your body makes new bone while it slows the breakdown of old bone. View abstract. Apostolidis N, Paradellis T, Karydas A, et al. N.Engl.J.Med. The naturally occurring form is made up of four stable isotopes: Sr-88 (82.6 percent), Sr-86 (9.9 percent), Sr-87 (7.0 percent), and Sr-84 (0.56 percent). Prostate cancer. J Bone Miner Res 2008;23(S80). 2012;23(3):1115-1122. doi: 10.1007/s00198-011-1847-z. The forms of strontium available over-the-counter in the U.S. or on the Internet are usually strontium citrate or strontium chloride. Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis. You can buy different forms of it, such as strontium citrate, in supplements at supermarkets and health food stores. Keep in mind that more research is still needed to confirm its benefits and safety for some of these uses. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. My bone density has shown some improvement and no further decline. 9-1-2005;30(17 Suppl):S84-S91. Strontium biokinetics in humans: influence of alginate on the uptake of ingested strontium. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Kishore A, Mehrotra KK, Saimbi CS. Scientists havent tested these supplements much, so theres not enough research to know if they fight osteoporosis. N.Engl.J.Med. My teeth are really strong and it feels like my bones are too. Its also used to create that alerting red color in emergency flares. For two years, 174 of the men received 2 grams of strontium ranelate per day while 87 men received a placebo. Olson, B. L., McDonald, J. L., Jr., and Stookey, G. K. The effect of strontium and fluoride upon in vitro plaque and rat caries. Basically, it is like you are consuming rocks. J.Dent. B., and Devogelaer, J. P. Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis. View abstract. Lo, G. H., LaValley, M., McAlindon, T., and Felson, D. T. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. A meta-analysis of chondroitin sulfate in the treatment of osteoarthritis. View abstract. Calcium and strontium metabolic studies in patients on CAPD. Is it even safe? 2008;67(12):1736-1738. Cochrane Musculoskeletal Group. View abstract. View abstract. Bone mass and markers of bone and calcium metabolism in postmenopausal women treated with 1,25-dihydroxyvitamin D (Calcitrol) for four years. View abstract. Performance Lab Flex - Best For Athletes. (Accessed 8 August 2006). (5a). Eisenberg E. Effects of androgens, estrogens and corticoids on strontium kinetics in man. Bolland, M. J., Grey, A. (16), Strontiums name comes from Strontian, a village in Scotland. Reginster, J., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., and Eastell, R. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. View abstract. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. Pearce, N. X., Addy, M., and Newcombe, R. G. Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. I wont name names, but some of the most well-known toothpastes for sensitive teeth include strontium in their formulas. FDA. What Is Secondary Prevention of Osteoporosis? A common therapeutic dose you will often seen recommended for boosting bone health is 680 milligrams per day. Radiother Oncol 1994;31:33-40. View abstract. Also, the FDA doesnt regulate supplements in the same way as prescription drugs, so it's not possible to know if if they are safe or work well or even how much of the main ingredient they contain. Strontium 89 in the treatment of pain due to diffuse osseous metastases: a university hospital experience. View abstract. 2010;6(12):4513-4521. A new desensitizing dentifrice: preliminary report. View abstract. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Thromb.Haemost. View abstract. Spine (Phila Pa 1976.) Does anyone take Forteo ? [2] Royal Osteoporosis Society. Strontium is a mineral found in seawater and soil. N Engl J Med 2004;350:504-6. J.Bone Miner.Res. View abstract. View abstract. J Endod 2002;28:34-5. View abstract. View abstract. Given that strontium test results are tied to the strontium ion, citrate is your best option to reap its bone-building benefits. Strontium results in an overestimation (up to 50%) of the increase in bone density using DXA methods.[3]. View abstract. The drug makes your bones stronger and lowers your chances of getting fractures. Reginster, J. Y., Deroisy, R., Dougados, M., Jupsin, I., Colette, J., and Roux, C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial. This technology we use to assemble our list depends on a variety of factors, including but not limited to the following: Brand Value: Every brand of strontium citrate . Quintessence.Int. Some quinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin, moxifloxacin (Avelox), and others. Reginster, J. Y. and Meunier, P. J. Strontium ranelate phase 2 dose-ranging studies: PREVOS and STRATOS studies. View abstract. Rheumatol.Int. Kobler, A., Kub, O., Schaller, H. G., and Gernhardt, C. R. Clinical effectiveness of a strontium chloride- containing desensitizing agent over 6 months: a randomized, double-blind, placebo-controlled study. View abstract. 1991;13(3):21-25. Mayo docs say it will stay in my system for up to three years. Reichenbach S, Sterchi R, Scherer M, et al. Minkoff S, Axelrod S. Efficacy of strontium chloride in dental hypersensitivity. J.Clin.Endocrinol.Metab 2007;92(8):3076-3081. FreshSplash/Getty Images. This family of meds give your natural bone production a chance to play catch-up by slowing or stopping resorption, when bones break down and release minerals such as calcium into your blood. No tummy upset this time, have been increasing very slowly as I am very med sensitive, so was on 40mg for 10 days and now 40mg one day and 80 mg every second day for a week, but the tiredness is difficult to put up with. Drug Ther Bull. Boron has been consumed for menstrual cramps and boric acid has been used vaginally for yeast infections, but evidence is limited. It is a member of the aragonite group. (4b) Another mineral containing strontium iscelestite, which is used in strontium metal alloys. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9. View abstract. J.Thromb.Haemost. Osteoporos.Int. Brand: Algaecal. Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss. View abstract. Strontium ranelate is available as a prescription medication in Europe and Australia, but it has not been approved by the FDA in the United Sates. 2012. 2002;17(3):449-454. 2008;19(4):503-510. Hip Intervention Program Study Group. View abstract. 2005 - 2023 WebMD LLC. View abstract. In Australia and some countries in Europe, a form of strontium called strontium ranelate (Osseor Protelos) is available as a prescription medication to treat and prevent osteoporosis and bone fractures. Theres not enough research to know if strontium fights osteoporosis. My teeth are really strong and it feels like my bones are too. It's not known if strontium contained in dietary supplements has these effects. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Rizzoli R, Chapurlat RD, Laroche JM, et al. If youre not into chemistry, then those scientific facts probably dont mean that much to you. Effects of strontium ranelate on spinal osteoarthritis progression. Recker R, Stakkestad J Weber T et al. Immune function. 2002;13(12):925-931. Calcium Citrate. Br.J.Clin.Pharmacol. Strontium ranelate has risks though. https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/ So what is stable strontium exactly? 2006;54(10):3205-3211. It also appears that people with strontium in their local water supply seem to have decreased cavity risk. Membership to ConsumerLab.com is available online and provides immediate access to reviews of more than 1,000 products from over 400 brands. Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy and Conditions of Use linked below. Strontium ranelate has never been approved in the U.S. Osteoporos.Int. Strontium Ranelate returns to the UK as an osteoporosis drug treatment. 2019, As a service to our readers, American Bone Health provides access to our library of archived content. Agency for Toxic Substances and Disease Registry. Strontium can attach to some antibiotics called quinolones in the stomach. For more information:Sr-89 chloride side effects. Hello @bonelady. You may be surprised, but strontium chloride hexahydrate is added to toothpaste to reduce the pain associated with sensitive teeth. A 2016 systematic review published in European Urology took a look at several radiopharmaceuticals including Sr-89 for reducing the malignant bone pain from prostate cancer. Liu, J. M., Wai-Chee, Kung A., Pheng, C. S., Zhu, H. M., Zhang, Z. L., Wu, Y. Y., Xu, L., Meng, X. W., Huang, M. L., Chung, L. P., Hussain, N. H., Sufian, S. S., and Chen, J. L. Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis. The American Bone Health Fracture Risk Calculator estimates fracture risk for women and men over age 45. View abstract. View abstract. Dermatol.Surg. J.Dent.Res. Before you consider calcium supplements, be sure you understand how much calcium you need, the pros and cons of calcium supplements, and which type of supplement to choose. Incorporation and distribution of strontium in bone. 2003;14 Suppl 3:S56-S65. View abstract. Seeman, E., Vellas, B., Benhamou, C., Aquino, J. P., Semler, J., Kaufman, J. M., Hoszowski, K., Varela, A. R., Fiore, C., Brixen, K., Reginster, J. Y., and Boonen, S. Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older.